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Is not effective when applied topically beyond some moisturizing effect Might help neutralize free radicals in skin, but evidence of effectiveness in skin is lacking

These typically occur during dose escalation and usually diminish as the body adjusts to treatment

Histologically, besides hyperpigmentation of basilar keratinocytes, lentiginous melanocytic hyperplasia may be observed in association with marked secondary epidermal rete hyperplasia, sometimes simulating the appearance of a reticulated seborrheic keratosis

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